When your fertility tests return normal, and yet conception remains elusive, it can be one of the most frustrating experiences. At the Nucleus IVF Centre in Pune under the care of Dr. Pritam Sulakhe, we understand that this scenario sometimes labelled “unexplained infertility”—is both common and emotionally challenging.
According to the Nucleus IVF Centre , unexplained infertility is diagnosed when a full fertility evaluation shows no identifiable cause, yet a couple remains unable to conceive. Here’s what to know—and what to do—when your tests look good but pregnancy isn’t happening.
Why “normal” results aren’t always the full story?
Even when hormonal panels, semen analysis, ovulation checks and structural imaging all come back within normal ranges, several hidden or subtle issues may be at work.
- Sub-optimal egg or sperm quality
While egg count and semen parameters may look acceptable, they do not always capture fine-quality issues: for example, eggs may carry chromosomal or mitochondrial defects, or sperm may have DNA fragmentation or functional abnormalities. - Implantation issues & uterine receptivity
Fertilization may occur, yet the embryo may fail to implant because the uterine lining isn’t sufficiently receptive, or there is a subtle defect in the endometrium or uterine environment.
- Undetected structural or immunologic issues
Conditions such as mild endometriosis, microscopic tubal damage, immune-system factors, or micro-vascular issues may evade standard tests yet impede conception. - Timing, lifestyle and environment
Even when biological systems appear normal, factors like timing of intercourse relative to ovulation, BMI, stress, environment (toxins, smoking), sleep and nutrition can influence outcomes.
What steps you can take guidance from Dr. Sulakhe and the Nucleus IVF team
- Re-examine timing & frequency of intercourse
Often overlooked: ensuring intercourse is well-timed is still key. Sperm may need to be present ahead of ovulation, and a narrow window exists for conception. - Lifestyle optimisation (for both partners)
Healthy weight, balanced diet, regular moderate exercise, avoiding smoking and excessive alcohol, limiting caffeine — these all support fertility. Nucleus IVF Centre highlights lifestyle changes as an important part of management of unexplained infertility. - Advanced diagnostic testing
If basic tests are all normal, consider deeper investigations: - Detailed sperm DNA fragmentation or functional assays
- Egg quality assessment (though limited)
- Uterine receptivity and endometrial evaluation
- Laparoscopic evaluation for subtle endometriosis or tubal pathology
- Immunologic testing if indicated
- Assisted reproductive options
When the cause remains elusive, treatment pathways such as intra-uterine insemination (IUI) or moving to in-vitro fertilisation (IVF) may be advised. According to Nucleus IVF Centre , even with unexplained infertility, many couples achieve pregnancy via ART. - Emotional & psychological support
The emotional toll of trying without visible reason can be heavy. At Nucleus IVF you’ll find support, counselling and a team approach to help manage stress and maintain wellbeing.
Why partner evaluation matters
It’s important not to assume fertility issues are only on the female side. Male-factor contributions (even subtle ones) can coexist with “normal” semen analysis results. A joint approach ensures neither partner is overlooked.
When to seek specialist advice
If you have been trying to conceive for 12 months (if under 35) or 6 months (if 35 or older) without success, even when tests appear normal, it’s time to consult a fertility specialist. At Nucleus IVF Centre, Dr. Pritam Sulakhe and the team provide tailored assessments and can map out personalised next steps.
Conclusion
A “normal” fertility report is a good start—but not always the end of the story. With modern reproductive medicine, many cases of unexplained infertility can be approached thoughtfully, combining lifestyle optimisation, careful timing, advanced diagnostics and, when required, assisted technologies.
At Nucleus IVF Centre in Pune, we believe every couple deserves a clear plan, compassionate care and the highest standards of investigation.
If you’d like, I can share a list of advanced fertility tests you might consider next, or walk you through what to expect at your first specialist consultation. Would you like that?
Dr. Pritam Prakash Sulakhe
